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Biomarker Encyclopedia

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Home/Biomarkers/Micronutrients & Vitamins/Vit E
Micronutrients & VitaminsLipid Peroxidation Chain Breaking

Serum Vitamin E (Alpha-Tocopherol) (Vit E)

Premier lipid-soluble chain-breaking antioxidant that protects polyunsaturated fatty acids in membranes and lipoproteins.

Standard Range5.5 - 18.0 mg/L
Optimal Longevity10.0 - 16.0 mg/L
Measurement Unitmg/L
Organ SystemLipid Peroxidation Chain Breaking
Routine Panels:Lipid Antioxidant Profile

Standard vs. Optimal Reference Rangesmg/L

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: mg/L
mg/L
Presets:
3 mg/LOptimal Zone Target25 mg/L
Optimal Longevity Zone(13 mg/L)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

5.5 - 18.0 mg/L

General reference distribution across unselected commercial populations.

Optimal Longevity Target

10.0 - 16.0 mg/L

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Transfers hydrogen atoms to lipid peroxyl radicals, terminating the autocatalytic lipid peroxidation chain reaction.

Differential Diagnosis

Elevated Levels (Vit E High)

  • •High-dose alpha-tocopherol supplementation

Low Levels (Vit E Low)

  • •Severe fat malabsorption (cystic fibrosis, cholestasis)
  • •Abetalipoproteinemia
  • •Ataxia with vitamin E deficiency

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Vitamin E (Alpha-Tocopherol) (Vit E) is critically involved in lipid peroxidation chain breaking. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Protects vascular endothelium and neuronal axons from oxidative injury; ratios should be adjusted for total lipids.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for Vit E
  • Targeted imaging or functional organ assessment related to lipid peroxidation chain breaking
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Serum Vitamin E (Alpha-Tocopherol) - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]Vit E in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Lipid Antioxidant Profile
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Vitamin E (Alpha-Tocopherol) (Vit E) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Micronutrients & Vitamins Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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