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Home/Biomarkers/Micronutrients & Vitamins/Vit A
Micronutrients & VitaminsVisual Cycle & Epithelial Health

Serum Vitamin A (Retinol) (Vit A)

Circulating fat-soluble retinoid transported by retinol-binding protein (RBP4) and transthyretin.

Standard Range30 - 80 ug/dL
Optimal Longevity40 - 70 ug/dL
Measurement Unitug/dL
Organ SystemVisual Cycle & Epithelial Health
Routine Panels:Fat-Soluble Vitamin Panel

Standard vs. Optimal Reference Rangesug/dL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ug/dL
ug/dL
Presets:
21 ug/dLOptimal Zone Target108 ug/dL
Optimal Longevity Zone(55 ug/dL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

30 - 80 ug/dL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

40 - 70 ug/dL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Converted to 11-cis-retinal for rhodopsin in the visual cycle and retinoic acid for nuclear RAR/RXR transcription.

Differential Diagnosis

Elevated Levels (Vit A High)

  • •Hypervitaminosis A (excessive supplementation)
  • •Severe renal failure (RBP accumulation)

Low Levels (Vit A Low)

  • •Dietary vitamin A deficiency (nyctalopia)
  • •Severe malabsorption and cholestasis
  • •Protein-calorie malnutrition

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Vitamin A (Retinol) (Vit A) is critically involved in visual cycle & epithelial health. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Essential for visual dark adaptation, mucosal epithelial integrity, and innate immune defense.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for Vit A
  • Targeted imaging or functional organ assessment related to visual cycle & epithelial health
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Serum Vitamin A (Retinol) - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]Vit A in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Fat-Soluble Vitamin Panel
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Vitamin A (Retinol) (Vit A) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Micronutrients & Vitamins Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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