Serum Vitamin A (Retinol) (Vit A)
Circulating fat-soluble retinoid transported by retinol-binding protein (RBP4) and transthyretin.
Standard vs. Optimal Reference Rangesug/dL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
30 - 80 ug/dL
General reference distribution across unselected commercial populations.
40 - 70 ug/dL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Converted to 11-cis-retinal for rhodopsin in the visual cycle and retinoic acid for nuclear RAR/RXR transcription.
Differential Diagnosis
Elevated Levels (Vit A High)
- •Hypervitaminosis A (excessive supplementation)
- •Severe renal failure (RBP accumulation)
Low Levels (Vit A Low)
- •Dietary vitamin A deficiency (nyctalopia)
- •Severe malabsorption and cholestasis
- •Protein-calorie malnutrition
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Vit A
- Targeted imaging or functional organ assessment related to visual cycle & epithelial health
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Vitamin A (Retinol) - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Vit A in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Vitamin A (Retinol) (Vit A) into overall healthspan optimization.