Soluble CD40 Ligand (sCD40L)
Transmembrane pro-inflammatory signaling protein shed into plasma primarily by activated circulating platelets.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
1.0 - 5.0 ng/mL
General reference distribution across unselected commercial populations.
<2.5 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds CD40 on endothelial cells and macrophages, inducing upregulation of tissue factor, adhesion molecules, and matrix metalloproteinases.
Differential Diagnosis
Elevated Levels (sCD40L High)
- •Active platelet activation and acute coronary syndromes
- •Unstable atherosclerotic plaques
- •Systemic lupus erythematosus
Low Levels (sCD40L Low)
- •Quiescent platelet status
- •Optimal antiplatelet therapy response
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for sCD40L
- Targeted organ system imaging or functional dynamic testing related to platelet activation & atherothrombosis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Soluble CD40 Ligand - The New England Journal of Medicine (2021). PMID: 33990124
- [2]sCD40L Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Soluble CD40 Ligand (sCD40L) into overall healthspan optimization.