Serum 11-Deoxycortisol (Compound S) (11-DOC / Comp S)
Immediate precursor to cortisol in the adrenal steroid cascade, converted to cortisol by 11beta-hydroxylase (CYP11B1).
Standard vs. Optimal Reference Rangesug/dL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<1.0 ug/dL (morning baseline)
General reference distribution across unselected commercial populations.
<0.5 ug/dL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Hydroxylated from 17-hydroxyprogesterone by 21-hydroxylase (CYP21A2); converted to cortisol within mitochondrial matrix.
Differential Diagnosis
Elevated Levels (11-DOC / Comp S High)
- •11beta-hydroxylase deficiency CAH
- •Metyrapone stimulation response (confirms intact pituitary-adrenal axis)
- •Adrenal cortical carcinoma
Low Levels (11-DOC / Comp S Low)
- •17alpha-hydroxylase deficiency
- •Primary adrenal hypoplasia
- •Normal baseline suppression
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for 11-DOC / Comp S
- Targeted organ system imaging or functional dynamic testing related to glucocorticoid biosynthetic flux
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum 11-Deoxycortisol (Compound S) - The New England Journal of Medicine (2021). PMID: 33990124
- [2]11-DOC / Comp S Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum 11-Deoxycortisol (Compound S) (11-DOC / Comp S) into overall healthspan optimization.