Serum Irisin (Irisin)
Peptide cleaved from the transmembrane fibronectin type III domain-containing protein 5 (FNDC5) during skeletal muscle contraction.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
50 - 250 ng/mL
General reference distribution across unselected commercial populations.
>120 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Induced downstream of PGC-1alpha; stimulates uncoupling protein 1 (UCP1) expression in white adipose tissue, driving thermogenic 'browning'.
Differential Diagnosis
Elevated Levels (Irisin High)
- •Regular vigorous aerobic and resistance exercise training (>120 ng/mL)
- •Cold temperature exposure
Low Levels (Irisin Low)
- •Sedentary lifestyle and physical inactivity
- •Metabolic syndrome and severe obesity
- •Accelerated cognitive aging
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Irisin
- Targeted organ system imaging or functional dynamic testing related to exercise myokine & adipose browning
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Irisin - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Irisin Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Irisin (Irisin) into overall healthspan optimization.