Plasma Interleukin-15 (IL-15)
Anabolic myokine synthesized and retained in skeletal muscle, presented in trans via IL-15R-alpha to circulating immune cells.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
1.0 - 5.0 pg/mL
General reference distribution across unselected commercial populations.
2.0 - 4.5 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Stimulates skeletal muscle myofibrillar protein synthesis, reduces visceral white adipose tissue mass, and supports CD8+ T and NK cell survival.
Differential Diagnosis
Elevated Levels (IL-15 High)
- •Regular resistance training adaptations
- •Optimal skeletal muscle mass
Low Levels (IL-15 Low)
- •Sarcopenia and frailty
- •Accelerated natural killer cell senescence
- •Visceral adiposity accumulation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for IL-15
- Targeted organ system imaging or functional dynamic testing related to myokine anabolic & nk cell survival
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Interleukin-15 - The New England Journal of Medicine (2021). PMID: 34190124
- [2]IL-15 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Interleukin-15 (IL-15) into overall healthspan optimization.