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Home/Biomarkers/Cardiovascular & Lipidology/Fibrinogen
Cardiovascular & LipidologyCoagulation Cascade & Rheology

Plasma Fibrinogen (Factor I) (Fibrinogen)

Hexameric hepatic glycoprotein serving as the precursor to insoluble fibrin clots and determinant of blood viscosity.

Standard Range200 - 400 mg/dL
Optimal Longevity200 - 300 mg/dL
Measurement Unitmg/dL
Organ SystemCoagulation Cascade & Rheology
Routine Panels:Advanced Coagulation PanelCardiovascular Risk

Standard vs. Optimal Reference Rangesmg/dL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: mg/dL
mg/dL
Presets:
140 mg/dLOptimal Zone Target540 mg/dL
Optimal Longevity Zone(250 mg/dL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

200 - 400 mg/dL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

200 - 300 mg/dL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Cleaved by thrombin to form fibrin monomers, cross-linked by Factor XIIIa into a stable clot.

Differential Diagnosis

Elevated Levels (Fibrinogen High)

  • •Acute phase response
  • •Atherosclerosis and smoking
  • •Post-operative trauma

Low Levels (Fibrinogen Low)

  • •Disseminated intravascular coagulation
  • •Severe liver failure
  • •Afibrinogenemia

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Plasma Fibrinogen (Factor I) (Fibrinogen) is critically involved in coagulation cascade & rheology. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Elevated levels increase blood viscosity and independently predict myocardial infarction and stroke.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for Fibrinogen
  • Targeted imaging or functional organ assessment related to coagulation cascade & rheology
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of Plasma Fibrinogen (Factor I) - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]Fibrinogen in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Advanced Coagulation PanelCardiovascular Risk
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Fibrinogen (Factor I) (Fibrinogen) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Cardiovascular & Lipidology Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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