Plasma D-Dimer (D-Dimer)
Specific cross-linked fibrin degradation fragment produced during plasmin-mediated clot lysis.
Standard vs. Optimal Reference Rangesug/mL FEU
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<0.50 ug/mL FEU
General reference distribution across unselected commercial populations.
<0.25 ug/mL FEU
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Generated when plasmin digests Factor XIIIa-crosslinked fibrin mesh, indicating active thrombus breakdown.
Differential Diagnosis
Elevated Levels (D-Dimer High)
- •Deep vein thrombosis
- •Pulmonary embolism
- •Disseminated intravascular coagulation
- •Severe sepsis
Low Levels (D-Dimer Low)
- •Absence of active thrombosis
- •Normal fibrinolytic baseline
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for D-Dimer
- Targeted imaging or functional organ assessment related to fibrinolysis & thrombosis
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Plasma D-Dimer - The New England Journal of Medicine (2021). PMID: 33890124
- [2]D-Dimer in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma D-Dimer (D-Dimer) into overall healthspan optimization.