Plasma Pantothenic Acid (Vit B5)
Water-soluble vitamin incorporated as the core functional backbone of Coenzyme A (CoA) and acyl carrier protein (ACP).
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.2 - 1.8 ug/mL
General reference distribution across unselected commercial populations.
0.4 - 1.2 ug/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Essential for acetyl-CoA generation, citric acid cycle entry, fatty acid beta-oxidation, and steroid hormone synthesis.
Differential Diagnosis
Elevated Levels (Vit B5 High)
- •Adequate dietary intake
- •Pantothenate supplementation
Low Levels (Vit B5 Low)
- •Severe dietary malnutrition
- •Impaired fatty acid oxidation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Vit B5
- Targeted organ system imaging or functional dynamic testing related to coenzyme a & fatty acid synthesis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Pantothenic Acid - The New England Journal of Medicine (2021). PMID: 33990124
- [2]Vit B5 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Pantothenic Acid (Vit B5) into overall healthspan optimization.