Urinary Triclosan (Triclosan)
Synthetic broad-spectrum chlorinated phenolic antimicrobial agent formerly widely added to antibacterial soaps, toothpastes, and household plastics.
Standard vs. Optimal Reference Rangesug/g Cr
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<10.0 ug/g Cr
General reference distribution across unselected commercial populations.
<2.0 ug/g Cr
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Inhibits bacterial enoyl-acyl carrier protein reductase (FabI); disrupts thyroid hormone deiodinases and alters gut microbiome microbial diversity.
Differential Diagnosis
Elevated Levels (Triclosan High)
- •Use of antibacterial personal care products, toothpastes, and antimicrobial household goods
Low Levels (Triclosan Low)
- •Avoidance of chlorinated antimicrobial agents
- •Optimal hepatic glucuronidation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Triclosan
- Targeted organ system imaging or functional dynamic testing related to chlorinated antimicrobial disrupter
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Urinary Triclosan - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Triclosan Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Urinary Triclosan (Triclosan) into overall healthspan optimization.