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Biomarker Encyclopedia

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Home/Biomarkers/Micronutrients & Vitamins/TAC / FRAP
Micronutrients & VitaminsNet Serum Antioxidant Power

Total Antioxidant Capacity (TAC / FRAP)

Integrated spectrophotometric measurement quantifying the cumulative capacity of all circulating antioxidants in plasma.

Standard Range1.0 - 2.0 mmol/L Trolox eq
Optimal Longevity1.3 - 1.8 mmol/L Trolox eq
Measurement Unitmmol/L eq
Organ SystemNet Serum Antioxidant Power
Routine Panels:Comprehensive Antioxidant Status

Standard vs. Optimal Reference Rangesmmol/L eq

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: mmol/L eq
mmol/L eq
Presets:
0 mmol/L eqOptimal Zone Target3 mmol/L eq
Optimal Longevity Zone(1.6 mmol/L eq)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

1.0 - 2.0 mmol/L Trolox eq

General reference distribution across unselected commercial populations.

Optimal Longevity Target

1.3 - 1.8 mmol/L Trolox eq

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Reflects the synergistic reducing potential of uric acid, albumin, ascorbic acid, alpha-tocopherol, bilirubin, and polyphenols.

Differential Diagnosis

Elevated Levels (TAC / FRAP High)

  • •High systemic antioxidant reserve and polyphenol-rich nutrition

Low Levels (TAC / FRAP Low)

  • •Systemic antioxidant depletion
  • •Severe chronic illness and critical care catabolism

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Total Antioxidant Capacity (TAC / FRAP) plays an essential physiological role in net serum antioxidant power. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Measures overall extracellular redox defense against acute free radical-mediated damage.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for TAC / FRAP
  • Targeted organ system imaging or functional dynamic testing related to net serum antioxidant power
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Total Antioxidant Capacity - The New England Journal of Medicine (2021). PMID: 33990124
  • [2]TAC / FRAP Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Common Panels:Comprehensive Antioxidant Status
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Total Antioxidant Capacity (TAC / FRAP) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Micronutrients & Vitamins Biomarkers

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hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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