Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)
Endogenous glycoprotein inhibitor that forms irreversible 1:1 non-covalent stoichiometric complexes with active matrix metalloproteinases.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
100 - 250 ng/mL
General reference distribution across unselected commercial populations.
120 - 200 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Inhibits collagen degradation while promoting myofibroblast survival and matrix accumulation, serving as a master driver of tissue fibrosis.
Differential Diagnosis
Elevated Levels (TIMP-1 High)
- •Active hepatic fibrogenesis (elevated in advanced MASLD and cirrhosis)
- •Myocardial interstitial fibrosis
- •Systemic sclerosis
Low Levels (TIMP-1 Low)
- •Balanced matrix turnover
- •Absence of progressive organ fibrosis
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for TIMP-1
- Targeted organ system imaging or functional dynamic testing related to matrix remodeling & fibrosis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Tissue Inhibitor of Metalloproteinases-1 - The New England Journal of Medicine (2021). PMID: 34090124
- [2]TIMP-1 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) into overall healthspan optimization.