Symmetric Dimethylarginine (SDMA)
Stereoisomer of ADMA eliminated almost exclusively via renal excretion, serving as an early marker of renal decline.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.30 - 0.75 umol/L
General reference distribution across unselected commercial populations.
<0.60 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Competes with arginine for cellular transport and accumulates proportionally to GFR reduction.
Differential Diagnosis
Elevated Levels (SDMA High)
- •Early chronic kidney disease
- •Glomerulonephritis
- •Renal hypoperfusion
Low Levels (SDMA Low)
- •Intact glomerular filtration
- •Normal renal plasma flow
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for SDMA
- Targeted imaging or functional organ assessment related to glomerular filtration & methylation
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Symmetric Dimethylarginine - The New England Journal of Medicine (2021). PMID: 33890124
- [2]SDMA in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Symmetric Dimethylarginine (SDMA) into overall healthspan optimization.