Serum Selenium (Se)
Essential trace element incorporated as selenocysteine into 25 human selenoproteins including glutathione peroxidases and deiodinases.
Standard vs. Optimal Reference Rangesug/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
70 - 150 ug/L
General reference distribution across unselected commercial populations.
100 - 140 ug/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Catalyzes reduction of hydrogen peroxide and lipid hydroperoxides (GPx) and deiodination of T4 into active T3.
Differential Diagnosis
Elevated Levels (Se High)
- •Selenosis (hair loss, garlic breath, nail dystrophies from excessive intake)
Low Levels (Se Low)
- •Keshan disease (endemic cardiomyopathy)
- •Impaired T4-to-T3 peripheral conversion
- •Elevated thyroid peroxidase antibodies (TPOAb)
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Se
- Targeted imaging or functional organ assessment related to glutathione peroxidase & selenoproteins
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Selenium - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Se in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Selenium (Se) into overall healthspan optimization.