Serum Progesterone (Prog)
Endogenous C-21 steroid hormone synthesized by the corpus luteum, placenta, and adrenal cortex, promoting GABAergic allosteric modulation and gestational support.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
0.1 - 25.0 ng/mL (phase dependent)
General reference distribution across unselected commercial populations.
>10.0 ng/mL (mid-luteal in females), 0.2 - 0.5 ng/mL (males)
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds PR-A and PR-B receptors to induce chromatin remodeling and converts to allopregnanolone to enhance GABAA chloride conductance.
Differential Diagnosis
Elevated Levels (Prog High)
- •Pregnancy
- •Congenital adrenal hyperplasia (21-hydroxylase)
- •Luteal cyst
Low Levels (Prog Low)
- •Anovulatory cycles
- •Luteal phase defect
- •Hypogonadism
- •Menopausal transition
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Prog
- Targeted imaging or functional organ assessment related to corpus luteum & neurosteroid homeostasis
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Progesterone - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Prog in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Progesterone (Prog) into overall healthspan optimization.