Serum Lipase (Lipase)
Pancreatic glycoprotein enzyme that hydrolyzes dietary triglycerides into fatty acids and glycerol.
Standard vs. Optimal Reference RangesU/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
10 - 60 U/L
General reference distribution across unselected commercial populations.
15 - 45 U/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Released into systemic circulation during pancreatic acinar necrosis; remains elevated longer than amylase (8 to 14 days).
Differential Diagnosis
Elevated Levels (Lipase High)
- •Acute pancreatitis (>3x ULN confirms diagnosis)
- •Pancreatic duct obstruction
- •Perforated peptic ulcer
- •Renal failure (reduced clearance)
Low Levels (Lipase Low)
- •Pancreatic exocrine insufficiency
- •Late-stage chronic calcific pancreatitis
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Lipase
- Targeted imaging or functional organ assessment related to pancreatic acinar necrosis
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Lipase - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Lipase in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Lipase (Lipase) into overall healthspan optimization.