Serum Leucine (Leu)
Potent ketogenic essential branched-chain amino acid that directly triggers Sestrin2-Rag GTPase activation of mTORC1.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
80 - 180 umol/L
General reference distribution across unselected commercial populations.
100 - 160 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds cytosolic sensor Sestrin2, releasing GATOR2 to activate Rag GTPases and recruit mTORC1 to lysosomes.
Differential Diagnosis
Elevated Levels (Leu High)
- •Dietary protein loading
- •Insulin resistance
- •Impaired branched-chain ketoacid dehydrogenase
Low Levels (Leu Low)
- •Sarcopenia and protein deficiency
- •Severe liver cirrhosis
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Leu
- Targeted imaging or functional organ assessment related to mtorc1 activation & anabolism
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Leucine - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Leu in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Leucine (Leu) into overall healthspan optimization.