Soluble ICAM-1 (sICAM-1 / CD54)
Soluble circulating form of intercellular adhesion molecule-1 shed from the luminal surface of activated vascular endothelial cells.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
100 - 300 ng/mL
General reference distribution across unselected commercial populations.
<180 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds leukocyte beta-2 integrins (LFA-1 and Mac-1), mediating firm leukocyte arrest and transendothelial migration into the subendothelial arterial intima.
Differential Diagnosis
Elevated Levels (sICAM-1 / CD54 High)
- •Active endothelial activation and vascular inflammation
- •Atherosclerotic plaque progression
- •Active cigarette smoking
- •Metabolic syndrome
Low Levels (sICAM-1 / CD54 Low)
- •Quiescent, non-activated vascular endothelium (<180 ng/mL)
- •Optimal nitric oxide bioavailability
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for sICAM-1 / CD54
- Targeted organ system imaging or functional dynamic testing related to endothelial leukocyte firm adhesion
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Soluble ICAM-1 - The New England Journal of Medicine (2021). PMID: 34190124
- [2]sICAM-1 / CD54 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Soluble ICAM-1 (sICAM-1 / CD54) into overall healthspan optimization.