Plasma Vasoactive Intestinal Peptide (VIP)
28-amino-acid neuropeptide localized in central and peripheral peptidergic neurons that stimulates profound intestinal secretion of water and electrolytes.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<75.0 pg/mL
General reference distribution across unselected commercial populations.
<50.0 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds VPAC1 and VPAC2 receptors on enterocytes, activating adenylyl cyclase/cAMP to stimulate massive CFTR chloride and water secretion.
Differential Diagnosis
Elevated Levels (VIP High)
- •VIPoma neuroendocrine tumor (plasma VIP often >200 pg/mL with secretory diarrhea)
- •Ganglioneuroma / Ganglioneuroblastoma
Low Levels (VIP Low)
- •Quiescent VIPergic neurotransmission
- •Normal basal intestinal secretion
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for VIP
- Targeted organ system imaging or functional dynamic testing related to wdha syndrome & intestinal secretion
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Plasma Vasoactive Intestinal Peptide - The New England Journal of Medicine (2021). PMID: 34190124
- [2]VIP Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Plasma Vasoactive Intestinal Peptide (VIP) into overall healthspan optimization.