Serum Malondialdehyde (MDA)
Highly reactive three-carbon dialdehyde formed as a principal secondary degradation product of polyunsaturated fatty acid peroxidation.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<1.0 umol/L
General reference distribution across unselected commercial populations.
<0.5 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Cross-links proteins and nucleic acids, forming mutagenic DNA adducts (M1G) and advanced lipoxidation end-products (ALEs).
Differential Diagnosis
Elevated Levels (MDA High)
- •Accelerated lipid peroxidation
- •Atherosclerotic cardiovascular disease
- •NASH and hepatic lipid stress
Low Levels (MDA Low)
- •Optimal cellular membrane integrity
- •Low systemic lipid oxidation
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for MDA
- Targeted organ system imaging or functional dynamic testing related to polyunsaturated lipid oxidation
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Malondialdehyde - The New England Journal of Medicine (2021). PMID: 33990124
- [2]MDA Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Malondialdehyde (MDA) into overall healthspan optimization.