Serum Interleukin-8 (IL-8 / CXCL8)
Pro-inflammatory CXC chemokine secreted abundantly by senescent cells as a core component of the Senescence-Associated Secretory Phenotype (SASP).
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<15.0 pg/mL
General reference distribution across unselected commercial populations.
<5.0 pg/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds CXCR1 and CXCR2 receptors on neutrophils and endothelial cells, driving neutrophil extracellular trap (NET) formation and tumor angiogenesis.
Differential Diagnosis
Elevated Levels (IL-8 / CXCL8 High)
- •High Senescence-Associated Secretory Phenotype (SASP) load
- •Active metastatic tumor microenvironment
- •Severe chronic inflammatory disease
Low Levels (IL-8 / CXCL8 Low)
- •Low systemic senescent secretory burden (<5.0 pg/mL)
- •Optimal tissue quiescence
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for IL-8 / CXCL8
- Targeted organ system imaging or functional dynamic testing related to sasp chemokine & neutrophil chemotaxis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Interleukin-8 - The New England Journal of Medicine (2021). PMID: 34090124
- [2]IL-8 / CXCL8 Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35322901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Interleukin-8 (IL-8 / CXCL8) into overall healthspan optimization.