Serum Inhibin B (Inhibin B)
Dimeric peptide hormone synthesized by testicular Sertoli cells in males and developing granulosa follicles in females.
Standard vs. Optimal Reference Rangespg/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
10 - 250 pg/mL (phase & sex dependent)
General reference distribution across unselected commercial populations.
Sertoli sufficiency >100 pg/mL (males), >45 pg/mL (early follicular)
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Selectively suppresses pituitary FSH secretion via negative feedback at the anterior pituitary gonadotrophs.
Differential Diagnosis
Elevated Levels (Inhibin B High)
- •Granulosa cell ovarian tumors
- •Early follicular recruitment
Low Levels (Inhibin B Low)
- •Sertoli cell damage / male infertility (azoospermia)
- •Diminished ovarian reserve
- •Perimenopause
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Inhibin B
- Targeted organ system imaging or functional dynamic testing related to sertoli cell & ovarian reserve
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Inhibin B - The New England Journal of Medicine (2021). PMID: 33990124
- [2]Inhibin B Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Inhibin B (Inhibin B) into overall healthspan optimization.