Glycoprotein Acetylation (GlycA)
Composite NMR spectroscopy biomarker measuring N-acetylglucosamine residues on acute-phase circulating glycoproteins.
Standard vs. Optimal Reference Rangesumol/L
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<380 umol/L
General reference distribution across unselected commercial populations.
<340 umol/L
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Reflects hepatic synthesis and glycosylation of alpha-1-acid glycoprotein, haptoglobin, and alpha-1-antitrypsin.
Differential Diagnosis
Elevated Levels (GlycA High)
- •Chronic low-grade vascular inflammation
- •Rheumatoid arthritis and autoimmune flares
- •Metabolic syndrome
Low Levels (GlycA Low)
- •Low systemic inflammatory burden
- •Optimal vascular quiescence
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for GlycA
- Targeted imaging or functional organ assessment related to systemic chronic inflammatory tone
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Glycoprotein Acetylation - The New England Journal of Medicine (2021). PMID: 33890124
- [2]GlycA in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Glycoprotein Acetylation (GlycA) into overall healthspan optimization.