Serum Galectin-3 (Gal-3)
Beta-galactoside-binding lectin secreted by activated macrophages that stimulates tissue fibroblast proliferation.
Standard vs. Optimal Reference Rangesng/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
<17.8 ng/mL
General reference distribution across unselected commercial populations.
<14.0 ng/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds cell surface glycoproteins and extracellular matrix, promoting collagen type I synthesis and crosslinking.
Differential Diagnosis
Elevated Levels (Gal-3 High)
- •Chronic heart failure progression
- •Kidney fibrosis and CKD
- •Liver cirrhosis
- •Systemic sclerosis
Low Levels (Gal-3 Low)
- •Low systemic fibrogenesis
- •Normal tissue remodeling
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker panel evaluation for Gal-3
- Targeted imaging or functional organ assessment related to myocardial & renal fibrosis
- Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Physiological Dynamics of Serum Galectin-3 - The New England Journal of Medicine (2021). PMID: 33890124
- [2]Gal-3 in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Galectin-3 (Gal-3) into overall healthspan optimization.