Complement Factor H (Factor H / CFH)
Major soluble glycoprotein regulator of the alternative complement pathway that protects host cells from self-directed complement attack.
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
300 - 650 ug/mL (30 - 65 mg/dL)
General reference distribution across unselected commercial populations.
350 - 550 ug/mL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Accelerates decay of the alternative C3 convertase (C3bBb) and acts as a cofactor for Factor I-mediated cleavage of C3b into inactive iC3b.
Differential Diagnosis
Elevated Levels (Factor H / CFH High)
- •Normal host cell alternative complement protection
Low Levels (Factor H / CFH Low)
- •Atypical Hemolytic Uremic Syndrome (CFH mutation / autoantibodies)
- •Dense Deposit Disease (MPGN Type II)
- •Age-Related Macular Degeneration high-risk genotype (Y402H)
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Factor H / CFH
- Targeted organ system imaging or functional dynamic testing related to alternative pathway soluble regulator
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Complement Factor H - The New England Journal of Medicine (2021). PMID: 34190124
- [2]Factor H / CFH Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35422901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Complement Factor H (Factor H / CFH) into overall healthspan optimization.