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Home/Biomarkers/Endocrinology & Hormones/Compound B
Endocrinology & HormonesGlucocorticoid Intermediate Metabolism

Serum Corticosterone (Compound B)

C-21 glucocorticoid and mineralocorticoid intermediate synthesized from 11-deoxycorticosterone by 11beta-hydroxylase.

Standard Range0.1 - 1.0 ug/dL
Optimal Longevity0.2 - 0.7 ug/dL
Measurement Unitug/dL
Organ SystemGlucocorticoid Intermediate Metabolism
Routine Panels:Adrenal Cascade ProfileSteroidomics

Standard vs. Optimal Reference Rangesug/dL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ug/dL
ug/dL
Presets:
0 ug/dLOptimal Zone Target2 ug/dL
Optimal Longevity Zone(0.4 ug/dL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

0.1 - 1.0 ug/dL

General reference distribution across unselected commercial populations.

Optimal Longevity Target

0.2 - 0.7 ug/dL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Serves as the major glucocorticoid in rodents and a minor circulating glucocorticoid and aldosterone precursor in humans.

Differential Diagnosis

Elevated Levels (Compound B High)

  • •17alpha-hydroxylase deficiency (diverts whole steroid flux into corticosterone pathway)
  • •Adrenocortical hyperplasia

Low Levels (Compound B Low)

  • •11beta-hydroxylase deficiency
  • •Addison disease

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Corticosterone (Compound B) plays an essential physiological role in glucocorticoid intermediate metabolism. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Evaluates complete adrenal steroidogenesis and localized tissue glucocorticoid/mineralocorticoid receptor selectivity.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for Compound B
  • Targeted organ system imaging or functional dynamic testing related to glucocorticoid intermediate metabolism
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Serum Corticosterone - The New England Journal of Medicine (2021). PMID: 33990124
  • [2]Compound B Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Common Panels:Adrenal Cascade ProfileSteroidomics
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Corticosterone (Compound B) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Endocrinology & Hormones Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
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