Serum Aldosterone (Aldo)
Principal mineralocorticoid steroid hormone synthesized in the adrenal zona glomerulosa, regulating renal sodium retention.
Standard vs. Optimal Reference Rangesng/dL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
3 - 30 ng/dL (upright posture)
General reference distribution across unselected commercial populations.
4 - 15 ng/dL
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Binds mineralocorticoid receptors (MR) in distal renal tubules and collecting ducts, upregulating ENaC channels and Na+/K+ ATPase pumps.
Differential Diagnosis
Elevated Levels (Aldo High)
- •Primary aldosteronism (Conn syndrome, adrenal adenoma)
- •Secondary aldosteronism (renovascular hypertension, CHF, cirrhosis)
- •Bartter syndrome
Low Levels (Aldo Low)
- •Primary adrenal insufficiency (Addison disease)
- •Hyporeninemic hypoaldosteronism (Type IV RTA in diabetes)
- •ACE inhibitor therapy
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for Aldo
- Targeted organ system imaging or functional dynamic testing related to renal sodium-potassium homeostasis
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of Serum Aldosterone - The New England Journal of Medicine (2021). PMID: 33990124
- [2]Aldo Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Aldosterone (Aldo) into overall healthspan optimization.