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Biomarker Encyclopedia

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Home/Biomarkers/Endocrinology & Hormones/Aldo
Endocrinology & HormonesRenal Sodium-Potassium Homeostasis

Serum Aldosterone (Aldo)

Principal mineralocorticoid steroid hormone synthesized in the adrenal zona glomerulosa, regulating renal sodium retention.

Standard Range3 - 30 ng/dL (upright posture)
Optimal Longevity4 - 15 ng/dL
Measurement Unitng/dL
Organ SystemRenal Sodium-Potassium Homeostasis
Routine Panels:Mineralocorticoid ProfileHypertension Evaluation

Standard vs. Optimal Reference Rangesng/dL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ng/dL
ng/dL
Presets:
2 ng/dLOptimal Zone Target41 ng/dL
Optimal Longevity Zone(9.5 ng/dL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

3 - 30 ng/dL (upright posture)

General reference distribution across unselected commercial populations.

Optimal Longevity Target

4 - 15 ng/dL

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Binds mineralocorticoid receptors (MR) in distal renal tubules and collecting ducts, upregulating ENaC channels and Na+/K+ ATPase pumps.

Differential Diagnosis

Elevated Levels (Aldo High)

  • •Primary aldosteronism (Conn syndrome, adrenal adenoma)
  • •Secondary aldosteronism (renovascular hypertension, CHF, cirrhosis)
  • •Bartter syndrome

Low Levels (Aldo Low)

  • •Primary adrenal insufficiency (Addison disease)
  • •Hyporeninemic hypoaldosteronism (Type IV RTA in diabetes)
  • •ACE inhibitor therapy

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, Serum Aldosterone (Aldo) plays an essential physiological role in renal sodium-potassium homeostasis. Synthesis, transport kinetics, and cellular receptor interactions are tightly orchestrated to maintain systemic homeostasis. Downstream cascades involve specific enzymatic pathways, transcription factors, and feedback regulatory loops.
Longevity Risk Architecture & Epidemiology
Excessive aldosterone drives resistant hypertension, hypokalemia, cardiac interstitial fibrosis, and endothelial damage.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker quantification for Aldo
  • Targeted organ system imaging or functional dynamic testing related to renal sodium-potassium homeostasis
  • Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Molecular Physiology of Serum Aldosterone - The New England Journal of Medicine (2021). PMID: 33990124
  • [2]Aldo Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Common Panels:Mineralocorticoid ProfileHypertension Evaluation
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate Serum Aldosterone (Aldo) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Endocrinology & Hormones Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
PreviousPlasma Renin Activity (PRA)Renal Physiology & ElectrolytesNextAldosterone-to-Renin Ratio (ARR)Endocrinology & Hormones