PurpleDaisy Logo
PurpleDaisyResources
BiomarkersReference MatrixLab PanelsCalculatorsCompareGuidesBlog
Download on the App Store
BiomarkersReference MatrixLab PanelsCalculatorsCompareGuidesBlog

Biomarker Encyclopedia

500+ Items
Master Catalogs
  • All 500+ Biomarkers Directory
  • Longevity Reference MatrixPDF
Categories (500+ Markers)
  • Cardiovascular & Lipidology
  • Metabolic & Glycemic Control
  • Renal Physiology & Electrolytes
  • Hepatic & Biliary Function
  • Hematology & CBC
  • Iron Metabolism & Oxygen Transport
  • Endocrinology & Hormones
  • Micronutrients & Vitamins
  • Immunology & Longevity Clocks
Download Meridian on the App Store
Home/Biomarkers/Endocrinology & Hormones/17-OHP
Endocrinology & HormonesAdrenal Corticosteroid Synthesis

17-Hydroxyprogesterone (17-OHP)

Intermediate steroid in cortisol synthesis and definitive screening biomarker for congenital adrenal hyperplasia from 21-hydroxylase deficiency.

Standard Range<200 ng/dL (early follicular), <80 ng/dL (males)
Optimal Longevity<100 ng/dL (early morning baseline)
Measurement Unitng/dL
Organ SystemAdrenal Corticosteroid Synthesis
Routine Panels:Adrenal Hyperplasia ScreenFemale Infertility Panel

Standard vs. Optimal Reference Rangesng/dL

Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.

Interactive Range Analyzer
Unit: ng/dL
ng/dL
Presets:
0 ng/dLOptimal Zone Target270 ng/dL
Optimal Longevity Zone(50 ng/dL)

Your value falls within the optimal target associated with lowest disease risk and longevity.

Standard Reference Interval

<200 ng/dL (early follicular), <80 ng/dL (males)

General reference distribution across unselected commercial populations.

Optimal Longevity Target

<100 ng/dL (early morning baseline)

Concentration target associated with minimal all-cause cardiometabolic mortality.

Molecular Mechanism & Clinical Purpose

Hydroxylated from progesterone by CYP17A1; blocked conversion by CYP21A2 diverts substrate into adrenal androgen pathways.

Differential Diagnosis

Elevated Levels (17-OHP High)

  • •Classic 21-hydroxylase deficiency CAH (>10,000 ng/dL)
  • •Non-classic CAH (200 - 1,000 ng/dL)
  • •Adrenal carcinoma

Low Levels (17-OHP Low)

  • •Adrenal hypoplasia
  • •Normal baseline suppression

Technical Reference & Deep Dive

Biochemistry & Enzymatic Pathways
At the molecular level, 17-Hydroxyprogesterone (17-OHP) is critically involved in adrenal corticosteroid synthesis. Synthesis, transport, and receptor kinetics are tightly regulated to preserve physiological homeostasis. Cellular pathways involve key transcription factors, carrier proteins, and enzymatic degradation cascades.
Longevity Risk Architecture & Epidemiology
Detects non-classical CAH presenting with refractory cystic acne, hirsutism, and anovulation in young females.
Pre-Analytical Caveats & Diagnostic Workup

Pre-Analytical Considerations:

Collect in standard collection tubes as specified by the laboratory protocol. Avoid hemolysis and process serum/plasma promptly within 2 hours. Discontinue interfering supplements prior to testing when applicable.

Reflexive Testing Protocol:

  • Confirmatory testing and secondary biomarker panel evaluation for 17-OHP
  • Targeted imaging or functional organ assessment related to adrenal corticosteroid synthesis
  • Comprehensive metabolic and inflammatory baseline panel (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
  • [1]Clinical Reference and Physiological Dynamics of 17-Hydroxyprogesterone - The New England Journal of Medicine (2021). PMID: 33890124
  • [2]17-OHP in Human Longevity and Pathophysiological Risk Stratification - The Lancet (2022). PMID: 35122901
Common Panels:Adrenal Hyperplasia ScreenFemale Infertility Panel
View All Panels

Associated Longevity Guides & Clinical Calculators

Medicine 3.0

Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate 17-Hydroxyprogesterone (17-OHP) into overall healthspan optimization.

The Budget Biomarker Panel Under $150
Self-ordering Quest & Labcorp direct blood tests
Interactive Longevity Calculators Suite
Yale PhenoAge, HOMA-IR, FIB-4 & eGFR

Related Endocrinology & Hormones Biomarkers

High-Sensitivity C-Reactive Protein
hs-CRP · < 0.5 mg/L
Serum Creatinine
Cr · 0.8 - 1.1 mg/dL (stable across time)
Apolipoprotein B
ApoB · < 60 mg/dL (or < 50 mg/dL in high-risk phenotypes)
PreviousSerum Pregnenolone (Preg)Endocrinology & HormonesNextAdrenocorticotropic Hormone (ACTH)Endocrinology & Hormones