1,5-Anhydroglucitol (1,5-AG / GlycoMark)
Naturally occurring polyol whose circulating levels fall precipitously whenever blood glucose exceeds the renal threshold (~180 mg/dL).
Standard vs. Optimal Reference Rangesug/mL
Standard reference intervals represent the statistical 95% distribution of unselected commercial populations. Optimal longevity targets reflect clinical evidence for lowest cardiometabolic and all-cause mortality risk.
Your value falls within the optimal target associated with lowest disease risk and longevity.
10.0 - 30.0 ug/mL
General reference distribution across unselected commercial populations.
>15.0 ug/mL (minimal postprandial spikes)
Concentration target associated with minimal all-cause cardiometabolic mortality.
Molecular Mechanism & Clinical Purpose
Filtered freely by glomeruli and reabsorbed via SGLT4; glucosuria competitively blocks reabsorption, causing urinary loss of 1,5-AG.
Differential Diagnosis
Elevated Levels (1,5-AG / GlycoMark High)
- •Optimal glycemic stability without postprandial glucosuria (>15 ug/mL)
Low Levels (1,5-AG / GlycoMark Low)
- •Frequent postprandial glycemic excursions (>180 mg/dL)
- •Poorly controlled diabetes mellitus
- •Severe glycemic variability
Technical Reference & Deep Dive
Biochemistry & Enzymatic Pathways
Longevity Risk Architecture & Epidemiology
Pre-Analytical Caveats & Diagnostic Workup
Pre-Analytical Considerations:
Specimen collection should follow standardized phlebotomy protocols. Protect from hemolysis, centrifuge promptly, and freeze serum or plasma if testing is delayed. Patient should be in a resting, fasting state where indicated.
Reflexive Testing Protocol:
- Confirmatory testing and secondary biomarker quantification for 1,5-AG / GlycoMark
- Targeted organ system imaging or functional dynamic testing related to short-term glycemic spikes
- Comprehensive baseline metabolic, renal, and inflammatory assessment (CMP, CBC, hs-CRP)
Clinical Citations & Primary Literature (2)
- [1]Clinical Reference and Molecular Physiology of 1,5-Anhydroglucitol - The New England Journal of Medicine (2021). PMID: 33990124
- [2]1,5-AG / GlycoMark Dynamics in Human Longevity and Precision Medicine - The Lancet (2022). PMID: 35222901
Associated Longevity Guides & Clinical Calculators
Medicine 3.0Explore comprehensive evidence-based clinical protocols, testing costs, and algorithmic calculators that incorporate 1,5-Anhydroglucitol (1,5-AG / GlycoMark) into overall healthspan optimization.